You guys are too paranoid on RPM. My 408 gets spun to 6200 regularly. (or at least it did prior to going with the new roller cam). Power probably peaks at 5800, but I need to run it to 6200 to get into the next gear and still feel like it is in the powerband. Bottum end consists of .010/.010 nodular crank, stock 3/8" rods w/ ARP bolts and TRW L2354 .030 forged pistons. Bottum end is balanced, I used the good bearings and the good barrel shaped rings (this motor had been rebuilt years ago and already had the forged pistons in it, cyclinder wear was good, so the choice was go another .010 to .040 or run it loose, I chose to just hone for new rings and run it loose, spec calls for .0025 piston/cyl, we are running .004 after rehone). I also run the 8" balancer from the 427 motors. A couple of things we did though, really help the bottum end. This is a 2 bolt block that was studded, then line honed, then decked square. This discussion on line hone got quite lenthy in another thread recently, but bottum line is taking the precautions to eliminate unnecessary stress on the crank make all the difference. Rod and crank clearances were checked and verified. In other words, other than dropping big bucks for an aftermarket crank, rods and big buck pistons, we built the performance potential into the shortblock by paying attention to the details. As most good engine builders will tell you, throwing $$ at parts won't cut it unless you pay attention to the even the little details.
I would not have any reserve to run a solid flat tappet in this shortblock and spin it 6800 and for all practical purposes, this is nothing more than a 396/325 shortblock with forged pistons instead of cast.