For what it is worth, here is my experience in painting a car in pieces. I have etch primed and applied primer surfacer to separate pieces of my 65 malibu. Each door, the hood, the trunk, and the remainder of the shell were painted separately as time allowed. What I noticed with painting piece by piece is that you waste so much paint. If you paint only the door one day, there is all that overspray that is lost as you go past the edges. This would not be lost if the door was on the car. Then of course, I always had paint left over in the gun cup, sometimes a half a cup, which has such limited pot life you end up throwing it away.
Also, I just finished assembling the fenders and doors on the car to see how they will fit. I chipped some primer off each fender and door no matter how careful I was. It is difficult to align panels without paint, it is more time consuming and frustrating in paint.
I have decided to now assemble my car totally, align everything the way I want the pieces to fit, and then I will remove the primed doors only to make for better jambing around the hinges. I will then reattach the doors and spray the car as one piece in base and clear. I will use much less paint and get it done in one or two days, instead of spending weeks doing it piece by piece.
I am a novice at painting, so take my opinion with that in mind. But I now see the disadvantages of painting in pieces as being too much for me, so I will do base and clear as one piece. Good luck on your project.