We've run 3.73's in all five of our V8 powered S10's. They are a little hard on gas for a long trip. We got about 16 mpg doing 65 mph from Binghamton, NY to Carlisle, Pa and back. The engine is a pretty much bone stock 350 SBC with a Edelbrock Performer cam and carb, dual 2 1/4" exhaust, TH350 with a 2800 stall converter, and rear tires are BFG 235/70/15's (so they're a little taller which helps keep the rpms down a little=better gas milage)