The most common configuration is offset in, center out, or opposite offset out. This way the exhuast piping can run close to the driveshaft tunnel then toward the be in position to exit closer to the outside of the car when it goes over the axle.
Unfortunately, that version of the Flowmaster also happens to be the most restrictive version. With Flowmasters, it's best to get the center-in, center-out configuration. Also with Flowmasters, it's important to get the biggest case that you can fit under your car.
Big O Dave
TC Member 1113
God, Family, Country, Chevrolet... and Volvos with 400 SBCs in them. To paraphrase the Chrismas carol:
"Oh what fun it is to ride with a HIDDEN Chevrolet!"
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