My single turbo combo uses some low budget components and has been really reliable.
Stock OE 1pc rear main seal roller block (1996)
Iron Vortec heads.
Eagle crank, Eagle H beam rods.
PRO Tru fordged pistons
Making power with a turbo is way easier on parts then other forms of power adders. And the side effects are smaller cams, tight converters and numerically lower gears, all of which makes a turbo car a joy to drive on the street.
Here is a link to a video of my car:
YouTube - Honk If Parts Fall Off, 9.244 @ 150.68
there is also a pump gas video in my signature.
It was my first car that I got when I was 14.
You can build a mild Twin setup, just because you want twins does not mean the combo would be "serious" power, and it also does not mean a stock block will not handle it.
Personally i prefer a single turbo. My car is simple and has a single Borg Warner S480 which is actually a turbo that is a replacement for a John Deere Tractor engine.
Yes a Dart block is great, but it may not be needed if the OP has goals of 650hp or less and plans to keep the RPM down below 7,000. I would look at some block fill with a stock 400 block, and i'd also warn that the machine work on the stock block could exceed what a new SHP block would cost new and ready to go from Carl.