just send anything that is from someone you don't know to the spam folder. don't ever reply to an email from someone you don't know- even if it is an "unsubscribe" tab in the mail. by replying to the email, you are telling them that it is a good email address, and even if they never send anything to you again, you are now going to wind up on even more spam lists. there are people that make good money just finding valid email addresses and selling them to other spammers.