Currently I'm running a Comp Cams 294S (248/248 duration @.050") solid flat tappet cam in my 468 with about 9.8:1 compression. This winter I'm having my heads milled to bump the compression up to 11:1 and am swapping my cam out to an Isky with 264/264 duration @ .050" with .630/.630 lift on a 110LSA. My current motor has gone a best of 12.1 @ 118MPH in the 1/4 mile. How much of a performance increase am I looking at by swapping cams & bumping compression up to 11:1?

Here's my motor combination:

454 +.060" (468ci)
Cast Crank, 4340 Forged Rods, L2399 Forged Pistons

"206" Closed Chambered Heads (106.6cc Combustion Chambers), Ported, Bowls Blended, Gasket Matched, Combustion Chambers Polished, 2.19/1.88 Valves

Comp Cams 294S 248 Duration @ .050", .595/.595 Lift, 110 LSA, Installed on a 106 Intake Centerline

Holley Strip Dominator Intake (Ported & Gasket Matched) w/ Holley 850 Double Pumper

Headers 2 1/8" Primaries Into 4" Collectors (Open Headers)

I should also mention that I am running 4.11 gears with a Super T10 4 speed.

Personally, I would stay with the same cam and bump the CR to 11:1. I think you will make more power that way.