I need a little help on my vacuum lines. I have a small block 350 with an Edelbrock performer intake and I just switched from an edelbroker performer carb to a holley 1850. The edelbrock had 4 total vacuum ports. 2 large ports of which I had my PCV hooked up the front and my power brakes to the rear. vacuum advance to the timed port and the small full manifold vacuum port plugged. On the intake I have a threaded tee with 2 lines one runs to the transmission and the other to the firewall (I am guessing the heater controls?)

The holley only has 1 large port and 2 small. My question is can I move the transmission and (heater?) vacuum line to the smaller full manifold vacuum port on the carb with a tee, put the PCV on the large carburetor port and run my power brakes off the intake manifold port? or is there a better way to do it?

sounds like that should work just fine.

You could also swap the two port manifold fitting for a three port one.
Use it for the power brake booster, tranny mod valve, and the heat/AC vent control.
Then, run the PCV and vacuum advance off the Holley.

Ok I put the power brakes dirctly on the manifold port they work great, I put the pcv on the large carburetor port with no problem, vacuum advance on the timed port on the carb and the transmission on the carbs full manifold vacuum port, but the transmission does not seem to be shifting correctly. It seems to take a very long time to shift between 1st and second and kind of hangs there for a while. I didn't do this before any ideas?

I'd run the vacuum for the tranny mod valve directly off a manifold port.