Not sure if the Holley 750 DP came with any instructions or not on tuning, I could of misplaced them.

What are some tips? I have only tuned vac. secondary carbs. I know the 750 DP has 4 mixture screws instead of two. Any rules to follow here?

Ive always put carb on and then used a vacuum gauge, to obtain the highest #. With jetting take car to track and get highest mph. This is where you start tuning.

Basically the same as the vacuum secondaries. Since there is are 4 mixture screws do you have to compromise any to get the vacuum # the same.

Nope they should all be fairley close