For a ballpark adjustment on a fresh carb, I will set the timing and get it warmed up. Then I get a buddy to get in the car and put it in gear (if it's a stick, I guess it doesn't matter so much), have him hold the brake, and I turn all the adjustment screws out about 2 turns. Next, turn all 4 of the screws in 1/8 turn at a time, waiting for the carb to adjust between adjustments. Keep doing this until your idle speed starts to drop, and back them off a 1/8 turn. This should be pretty close to where you want to be, but can get better.
For final idle mixture turning, I make sure I have the timing set and the engine warmed, like above, then I set the mixture screws by tapping on the accelerator pump to give the engine a quick shot of fuel, but without cracking the throttle open. If the engine speeds up, the mixture is lean, if it stumbles, the mixture is rich. If there is no change, you're pretty much there. I do this by adjusting the primary side first, adjusting the mixture screws equally every time by 1/8 turn, and allowing a few moments for the carb to adjust to the settings. Then I move to the secondary side, doing the same thing. Finally I do both at the same time, adjusting all 4 mixture screws at once, but with smaller adjustments. I've never had much luck with the vacuum gauge method myself.